10 Vulnerability and Threat Management Best Practices

Explore 10 key threat and vulnerability management best practices for detection, assessment, and mitigation. Learn how SentinelOne boosts security with AI-driven tools for all environments.
By SentinelOne March 26, 2025

We are already three months into 2025, and the threat actors are more active than ever. With generative AI now becoming integrated into various business operations, 46 percent of security professionals are concerned about new vulnerabilities. Furthermore, the absence of a proper framework and strategy puts the organization and its assets at the mercy of continuously evolving criminals. However, applying threat and vulnerability management best practices can help businesses identify and evaluate current threats, and establish protective measures to counter threats before they worsen.

In this article, we will define what threat and vulnerability management is, why it is important for every organization regardless of its size, and how it can be incorporated with risk assessment frameworks. We will also discuss how the use of vulnerability management and threat intelligence can produce valuable information to counter cyber threats. At the end of this article, you will comprehend the key elements of a good defense that meets the compliance requirements and strengthens your IT systems.

What is Threat and Vulnerability Management?

Threat and vulnerability management is the process of protecting digital assets from threats using technology, process frameworks, and human expertise. This can be defined as the process of finding and categorizing defects in software, hardware, and networks, then eradicating them. A good threat and vulnerability management process also includes newly discovered threats, unknown threats, and known threats, associating each with risks.

Data shows that 71% of cyber leaders at the 2024 Annual Meeting on Cybersecurity stated that small organizations are at a tipping point when it comes to coping with cyber risks. This is why there is a need for a more comprehensive strategy that includes both technology and preparedness at the organizational level.

Fundamentally, vulnerability and threat management is not just about fixing things but about how one defines a risk and how this risk relates to a given weakness. Evaluating the likelihood of exploitation, attack patterns and current controls can help security teams identify where to focus their efforts in terms of fixes that would make the most impact. The aim is to develop a threat and vulnerability management process that is constantly on the lookout for threats and vulnerabilities, acts quickly on them, and effectively communicates with departments. It helps IT and security managers to plan proactively, fix critical problems, and be in compliance with the rules and regulations of the industry. Without this strategic lens, organizations can continue to simply apply patches to software individually, without seeing how they relate to current attack patterns.

Vulnerability and Threat Management Best Practices: 10 Actionable Tips

When it comes to combating threat actors, some of the best practices in threat and vulnerability management can make a big difference. In a recent survey of CEOs across the world, 74 percent of respondents agree that building a robust cyber culture is essential before implementing AI. In this section, you will find ten practical steps to create an end-to-end defense strategy, including vulnerability and threat assessment and the utilization of vulnerability management and threat intelligence. Every suggestion is accompanied by an example of how it can be applied in practice, which helps businesses to implement the idea consistently.

1. Establish a Comprehensive Asset Inventory

The first step in any good threat and vulnerability management process is to make sure that you have a good inventory of assets. This way, by categorizing servers, applications, endpoints, and IoT devices, security teams get a clear understanding of what requires protection and how scanning schedules should be arranged. This approach is very useful in deciding which system should be patched first, especially when new threats are identified. It also provides an updated list for performing periodic scans for unregistered or “shadow” devices that can potentially harbor unknown flaws. Also, it is impossible for a business to defend an asset which is not included in the inventory list.

Example:

Let us consider a mid-sized manufacturing firm that entered a new market of cloud services. Their security team knows where all their cloud instances and on-prem servers are and how they are tagged based on function and criticality. When a serious remote code execution vulnerability is discovered, they quickly identify which computers are running the compromised software. This way, they can promptly handle the problem while aligning with threat and vulnerability management best practices by prioritizing the most critical assets.

2. Conduct Periodic Vulnerability and Threat Analysis

Scanning and analysis are the two key activities that define vulnerability and threat management. Automated scanners identify known exploits while the code and signature reviews, along with threat intelligence, give information on new and developing threats. The integration of discovery with risk scoring allows teams to categorize vulnerabilities into critical, high, medium, and low priority based on exploit maturity and impact. These vulnerability and threat assessment activities should be performed periodically with frequencies adjusted in accordance with the organization’s risk appetite, legal obligations, and rate of technological advancements.

Example:

A healthcare provider must ensure compliance with HIPAA rules that call for risk analysis to be conducted on a regular basis. In particular, they use various specialized healthcare scanners to examine electronic health record systems for critical software vulnerabilities. As soon as new threats are identified that exploit medical device interfaces, the security team modifies scanning parameters and increases scrutiny. This reflects the best practice of threat and vulnerability management, where no flaw is left unaddressed and each relevant system is reassessed.

3. Classify and Prioritize Vulnerabilities

As more and more threats are identified with increasing frequency, it becomes imperative to differentiate between the signal and the noise. It is very important to classify and prioritize the weaknesses in order to have a focused threat and vulnerability management program. Frameworks such as the Common Vulnerability Scoring System (CVSS) and adding context on parameters like exploit frequency and the sensitivity of data, the security team can easily identify which specific gaps are most dangerous. This approach allocates resources where they will be most effective by focusing on the areas that will provide the most significant improvement.

Example:

An international bank with numerous data centers assigns a business consequence rank to each server, ranging from critical finance operations to reporting. When these servers are scanned for vulnerabilities, the analysts layer public exploit reports and the bank’s internal intelligence. They identify a fully operational buffer overflow attack vector on a payments platform that is currently being used by various hackers. By addressing that system right away, they illustrate threat and vulnerability management principles—handle the most critical problems first.

4. Integrate Vulnerability Management and Threat Intelligence

Incorporating vulnerability management with threat intelligence makes it possible to identify new exploits associated with known vulnerabilities. Threat intelligence allows for a more realistic understanding: Are cybercriminals exploiting a certain weakness at the moment? Is there any zero-day exploit that is available in the public domain? Introducing these details into a threat and vulnerability management program improves the decision-making process of prioritization and brings more subtle approaches to remediation. The integration of scanning tools with external intelligence enhances the coverage of the environment, unlike solely relying on the vulnerability databases that are often outdated.

Example:

An e-commerce firm is getting a number of threat intelligence feeds that center on retail malicious software. Learning that an exploit chain affects a payment gateway plugin that is widely used, the intel prioritizes it as high-risk. The company verifies this information with its weekly vulnerability scan, where it discovered that 20% of its web servers are using this specific plugin. In immediate patch deployment, they explain how threat and vulnerability management practices use real-time intelligence to prevent attacks.

5. Establish a Clear Remediation and Patch Schedule

Detection is useless if the vulnerabilities are left open and can be exploited for a long time. To ensure an effective vulnerability and threat management, patching should be scheduled in a rational way that takes into account operational requirements. Such a schedule is based on the severity of the problem—critical changes are made within a day, while less urgent ones can be implemented in a week or even two. This formalization of intervals and escalations helps to prevent any serious weaknesses from arising due to lack of clarity or responsibility. Also, documenting each patch cycle aids in the tracking of compliance as well as the improvements made.

Example:

A global retail brand uses a patch cycle, which is also structured in weeks or months where updates are bundled together. Whenever a critical issue arises with its point-of-sale systems, the process goes to the emergency mode and patches it within 48 hours. This way the retailer is not only protecting itself from increased exposure but also proving its compliance with the set deadlines. This is a good example of threat and vulnerability management best practices, which are oriented towards timely action.

6. Continuously Monitor Cloud Environments

An increasing number of enterprises are choosing to move their data and workload to public, private, or hybrid clouds. Although the cloud providers have certain measures in place to ensure security, the primary responsibility always falls on the client organization. It must include a comprehensive threat and vulnerability management process to scan the configurations, virtual machines, containers, and Kubernetes clusters in these cloud environments. The real-time cloud monitoring tools coupled with identity and access management systems alert the organization when there is an attempt to compromise, or a misconfiguration has been made that can lead to a breach.

Example:

A tech startup hosts its microservices on AWS but retains an on-prem DevOps pipeline. To centralize security, the startup also implements the continuous scanning rules that can scan the cloud stack and the local servers. For example, if a misconfigured S3 bucket is discovered to be publicly accessible, the system immediately notifies the administrators and corrects the issue. Such a combined solution highlights the security and risk mitigation across multi-cloud or hybrid environments with no gaps.

7. Conduct Regular Penetration Testing

While automated tools show pre-discovered security weaknesses, penetration testers can expose unnoticed logical flaws or interactions. Pentesting is a good way of making sure that the threat and vulnerability management program does not become stale and overly dependent on routine scans. Ethical hackers are highly trained professionals who recreate real-world threats, linking minor vulnerabilities into critical pathways. The result is a more profound view of organizational vulnerabilities – where teams are able to focus on the areas that need structural enhancements that may be beyond the scope of the ordinary scanners.

Example:

A financial services provider conducts monthly vulnerability assessment, but also employs the services of a professional pentesting firm at least twice each year. While most of the scans are clean, the testers identify a multi-stage exploit using authentication tokens in an obscure internal API. The provider quickly addresses this weakness and improves security scans to identify such problems in the future. This approach shows how threat and vulnerability management should be done in a way that combines automated processes and human analysis.

8. Develop a Sound Incident Response Team

Even the best of the plans to manage the risks of vulnerabilities and threats are still not able to protect against all threats. When an incident happens, it is crucial to act quickly to prevent further damage or a complete wipe out. This is why the members of the incident response team (IRT) must be aware of internal systems, procedures for escalation, and working with external partners. By integrating them into the overall threat and vulnerability management process, discovered vulnerabilities are not only addressed to fix, but also contribute to enhanced detection rules and communication between teams.

Example:

In a large telecommunication services provider, the IRT conducts monthly simulation exercises where the scenarios are imaginary breaches. When the team encounters a real intruder who uses an unpatched file-sharing service, they have a clear plan of action: Quarantine the affected host, block malicious IPs, and start advanced analysis. This swift action, based on a comprehensive threat and vulnerability management plan, helps to curb the breach before the customer’s information is compromised.

9. Create a Security-First Culture and Governance

While threat and vulnerability management may be dependent on technology, the culture of an organization is just as important. This means that all employees in the organization, no matter if they work in HR, marketing, or the finance department, should know the basics of cybersecurity and how to detect phishing attacks, and how to create a strong password. Security governance structures, for example, committees or boards, can be established to monitor and implement policies as well as allocate resources. When these governance mechanisms are in sync with the technical scanning and patching cycles, the whole enterprise stays protected.

Example:

An automotive manufacturer establishes a security governance council that is supposed to meet once a quarter. This council tracks average time to patch, most critical vulnerabilities that remain unpatched, and staff training completion rates. They make sure that any gap—such as slow patch rollout in the manufacturing plant—is quickly addressed. Through the integration of technology with leadership, they expand vulnerability and threat identification beyond IT employees to the rest of the employees.

10. Continuously Refine and Evolve Your Strategy

Threats and vulnerabilities are dynamic and evolve over time, making it vital to keep iterating the threat and vulnerability management program. Teams must remain agile through weekly review of threat intelligence, scanning tools, and the remediation process. This means changing policies, switching to better solutions when needed, or reassigning duties when there are gaps. Establishing measurements such as mean time to detect or mean time to patch also helps in tracking the progress and finding out what slows down the process of remediation.

Example:

A multinational logistics company conducts post-mortems on a quarterly basis, including all identified risks and the time taken to address them. The findings show that the work of a particular area often causes the postponement of updates for outdated warehousing systems. With these insights in mind, leadership implements cross-training and proper resource distribution. This closed-loop feedback is a great example of threat and vulnerability management best practices—the strategy develops as threats and operational environments change.

How SentinelOne Strengthens Threat and Vulnerability Management?

SentinelOne provides an AI-powered, cloud-based platform that enhances the conventional threat and vulnerability management approach by integrating scanning, detection, and response in a single console. At the center of its offering is Singularity™ Cloud Security, a CNAPP that protects every stage of a company’s cloud journey, from build time to runtime across public, private, and on-premises environments. This integrated model provides end-to-end visibility, enables security to manage auto-remediation and drive risk-based policies across scale.

SentinelOne’s hyper-automation and superior threat intelligence strengthen your vulnerability management and threat intelligence workflow, allowing you to identify and mitigate risks. In addition, it covers all workloads, including containers, virtual machines, serverless, and even databases, which do not leave coverage gaps that attackers can take advantage of. By employing local artificial intelligence engines that prevent such behavior in real-time, SentinelOne reduces the time that threats can dwell in a network.

With the help of advanced analysis, SentinelOne goes beyond the traditional cloud protection solutions, using detailed data and graph-based inventory. There are no kernel dependencies, which helps in easy deployment and the runtime protection that can prevent an exploit or a bad configuration from getting through.

Organizations get visibility into misconfigured cloud environments, code repositories, and shift-left container registries, which is important for an effective threat and vulnerability management strategy. Verified Exploit Paths™ lead to the most significant threats, while CI/CD pipeline scans guarantee a secure software delivery process. It also supports secret scanning, AI pipeline discovery, and multi-cloud compliance assessment, which covers the whole threat and vulnerability management lifecycle. Whether you are dealing with known CVEs or with newly identified ones, the solution offers multiple tools such as CSPM, CDR, CIEM, KSPM and many more that help to enhance the cloud security while incurring minimal overhead.

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Conclusion

A strategic vulnerability and threat management approach involves continuous identification, accurate categorization, and immediate mitigation. By combining detection, patching, and governance into a cohesive approach, organizations can create significant progress against both the lowly ransomware crews and the sophisticated nation-state groups and everyone in between. From daily or weekly asset list updates to vulnerability management and threat intelligence, these protective measures turn reactive processes into well-coordinated defense strategies.

Understand that there is no perfect solution or a single bulletproof policy that can protect against all threats. This is because cybersecurity is a constantly developing field that requires constant learning and improvement. However, companies that have implemented threat and vulnerability management best practices are much more prepared for such changes and are ready to face all possible threats with the help of known and unknown methods.

Ready to elevate your cloud security approach? Discover how to use SentinelOne Singularity™ Cloud Security for AI-based threat protection, deep misconfiguration scans, and automation. Protect your assets from build time to runtime and bolster each level of your threat and vulnerability defense.

FAQs

What are the best practices for threat and vulnerability management?

The first step that organizations should take is to ensure they have an inventory of all assets, and the second is to perform periodic vulnerability scans and categorization. Next, link vulnerability management and threat intelligence so that one can get updates on active exploits in real-time. It is also important to outline clear escalation procedures to fix critical issues and to ensure that such vulnerabilities are patched as soon as possible. Lastly, encourage a security-oriented culture that periodically revisits policies, simulates the response mechanism, and optimizes threat and vulnerability management.

How does the threat and vulnerability management process improve security?

A structured threat and vulnerability management process involves the identification of potential threats in the system and their corresponding vulnerabilities before attackers can exploit them. By using scanning, analysis, and prioritization, teams manage the most important problems first. This systematic cycle also encourages accountability since all employees understand their role in identifying, reporting, and correcting issues. The integration of these elements leads to the reduction of insecure areas and improved response to newly discovered vulnerabilities.

What are the key elements of a successful threat and vulnerability management program?

A robust threat and vulnerability management program integrates the identification of threats and vulnerabilities, their assessment, mitigation, and ongoing monitoring into a single process. It includes tools for linear scans or simple pentesting, clear documentation of patches, and timely responses from the incident response team. The commitment of leaders guarantees the provision of sufficient funds and resources for the integration of the required technologies and training. Therefore, it is important to consider the ability to change, the constant reassessment, and the organization’s compliance with the ever-changing regulatory and threat environments.

How does threat intelligence enhance vulnerability management?

Vulnerability management and threat intelligence are cyclic processes and point out which newly discovered weaknesses attackers use in the wild. By mapping external threat data over the scan results, the side of security gets a better understanding of which of these issues requires attention. This optimizes the use of resources, since personnel is not bogged down by theoretical threats, but is instead centered on actual threats. It also helps organizations stay flexible, changing detection and patching priority whenever a new campaign or exploit version is identified.

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